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Extended Topoisomerase 1 Inhibition Through Liposomal Irinotecan Results in Improved Efficacy Over Topotecan and Irinotecan in Models of Small-Cell Lung Cancer
SC Leonard et al. Anticancer Drugs 28 (10), 1086-1096.
Liposomal irinotecan (irinotecan liposome injection, nal-IRI), a liposomal formulation of irinotecan, is designed for extended circulation relative to irinotecan and for exploiting discontinuous tumor vasculature for enhanced drug delivery to tumors. Following tumor deposition, nal-IRI is taken up b ...
N1-Guanyl-1,7-Diaminoheptane Enhances the Chemosensitivity of Acute Lymphoblastic Leukemia Cells to Vincristine Through Inhibition of Eif5a-2 Activation
Y Liu et al. Anticancer Drugs 28 (10), 1097-1105.
N1-guanyl-1,7-diaminoheptane (GC7), a deoxyhypusine synthase inhibitor, has been shown to exert antiproliferation effects in many solid tumors by regulating eukaryotic translation initiation factor 5a2 (eif5a-2). However, little is known about the role of GC7 and eif5a-2 in drug resistance in acute ...
Ability of Polymer-Bound P-Glycoprotein Inhibitor Ritonavir to Overcome Multidrug Resistance in Various Resistant Neuroblastoma Cell Lines
E Koziolov√° et al. Anticancer Drugs 28 (10), 1126-1130.
Polymer prodrugs can considerably improve the treatment of tumors with multidrug resistance, often caused by overexpression of P-glycoprotein (P-gp). Here, we present the effect of the N-(2-hydroxypropyl) methacrylamide-based polymer conjugate with P-gp inhibitor ritonavir (RIT) on the increase of f ...
Two Faces of Hippo: Activate or Suppress the Hippo Pathway in Cancer
J Cao et al. Anticancer Drugs 28 (10), 1079-1085.
The Hippo pathway has generated considerable interest in recent years because of its involvement in several key hallmarks of cancer progression and metastasis. Research on the Hippo signaling pathway in cancer has been used to determine the activity of yes-associated protein (YAP) in tumorigenesis a ...
  • Review Article
Gallic Acid Induces G1 Phase Arrest and Apoptosis of Triple-Negative Breast Cancer Cell MDA-MB-231 via P38 Mitogen-Activated Protein Kinase/P21/P27 Axis
HL Lee et al. Anticancer Drugs 28 (10), 1150-1156.
Gallic acid (GA) possesses potential antitumoral activity on different types of malignancies. In this study, we aimed to explore the antitumoral effects of GA on triple-negative breast cancer (TNBC) cells, the breast cancer cells showing resistance to hormonal therapy or HER2 receptor targeting ther ...