Infections
• Acute
Viral (viral hepatitis, infectious mononucleosis, CMV infection)
Bacterial (septicemia, salmonellosis, brucellosis, splenic abscess)
Parasite (toxoplasmosis)
• Subacute and Chronic
Subacute bacterial endocarditis
Tuberculosis
Malaria
Kala-azar
Fungal disease
Inflammation
Felty syndrome
SLE
Serum sickness
Rheumatic fever
Sarcoidosis
ALPS
Congestive Splenomegaly
• Intrahepatic
Cirrhosis
• Extrahepatic
Portal vein obstruction
Splenic vein obstruction
Hepatic vein occlusion (Budd-Chiari syndrome)
• Chronic Passive Congestion
Heart failure
Hematologic Disorders
RBC disorders: hemolytic anemias, thalassemia, sickle cell disorders
Neoplasia
• Malignant
MPDs
Myeloid metaplasia
Polycythemia rubra vera
Essential thrombocythemia
Chronic leukemia
Chronic myeloid leukemia
Chronic lymphocytic leukemia
Hairy cell leukemia
Lymphoma
Acute leukemia
Malignant histiocytosis
• Benign
Hamartoma
Hemangioma
Lymphangioma
Fibroma
Storage Diseases
Gaucher disease
Niemann-Pick disease
Miscellaneous
Amyloidosis
Cysts
Note: ALPS, Autoimmune lymphoproliferative syndrome; CMV, cytomegalovirus; MPD, myeloproliferative disorder;